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World Kidney Day: "Kidneys in good health: it’s important, for everyone!" colloquium

Thursday 26th March 2015 at the Académie nationale de Médecine/National Academy of Medicine (Paris, 6th Arrondissement)
Like every year on World Kidney Day, the ITMO Physiopathology, metabolism, nutrition, the Kidney foundation, and the learned Nephrology societies organise a meeting between researchers, health professionals, patients, and patient associations. The 2015 edition of this meeting concerned the genetic and environmental factors of kidney disease, but also the feelings of the patients and the disparity of access to care and treatment.
Programme
Watch the presentations delivered by the day’s speakers

German‐French Retreat 2015 - Helmholtz Research School “Lung Biology and Disease”

24th‐27th March 2015 – Tegernsee
This annual retreat is part of the Franco-German cooperation programme on Pneumology.
Programme edition 2015

French-German Summer school on “Integrative biology in metabolic and cardiovascular diseases”

March, 15th to 19th, 2015- Maffliers (Val d’Oise)
The Franco-German summer school "Integrative biology in metabolic and cardiovascular diseases" was organised by the ITMO PMN in partnership with the Max-Delbrück centre for Molecular Medicine (MDC) in Berlin and 3 University hospital departments in the Ile de France: DHU AUTo-immune and HORmonal diseaseS – Necker/Cochin Hospital – Paris-Descartes University, DHU Unmet Needs for Innovation in HepaTology and GastroenterologY – Bichat/Beaujon hospital / Paris-Diderot University, DHU CRAP (Common and Rare Arterial Pathologies – Georges-Pompidou European Hospital / Paris-Descartes University
The summer school was supported by the Franco-German University.
Programme and website

"Therapeutic innovation" colloquium

18th and 19th December 2014 (Buffon auditorium - Paris-Diderot University - Paris 13th Arrondissement)
This colloquium was co-organised by the Multi-Organisation Thematic (ITMO) Circulation, Metabolism and Nutrition (CMN) and Health Technologies (TS) Institutes with the aim of presenting examples of successful therapeutic innovations in the areas of research covered by ITMO CMN, to give the researchers a better understanding of the potential of their research for innovation, and to inform them of the pathway leading to the exploitation of their results.The colloquium was opened with an introductory lecture given by Herman Waldmann (Therapeutic Immunology Group – University of Oxford) on the use of therapeutic antibodies to control the tolerance mechanisms of the immune system. It was closed by a Round Table which led to both an academic and industrial outlook of therapeutic innovations and a discussion on the issues.
Programme

1st Franco-German Symposium on Diabetes Research

11th and 12th December 2014 at the French Embassy in Berlin
This symposium, co-organised by the French Embassy, the German Centre for Diabetes research (DZD) and the ITMO (Multi-Organisation Thematic Institute) Circulation, Meetabolism and Nutrition, in partnership with Sanofi, brought together French and German experts in fields covering research on beta cell biology, interactions between organs and tissues, the involvement of the immune system and the influence of the environment on diabetes. The aim was to bring the French and German scientists together, to promote discussion and encourage collaborations. It laid the foundations for a French-German Academy for diabetes research.
Programme

1st Meeting of Foundations and Associations for Research on Rheumatic and Musculoskeletal Diseases "Ageing Well Without Rheumatic or Musculoskeletal Diseases"

Monday 13th October 2014 - Pavillon de l’Eau/Water Pavilion (Paris 16th Arrondissement)
This meeting was co-organised by Inserm, Aviesan, the Courtin Arthritis Foundation and the French Society for Rheumatology (with its endowment fund, "France Rhumatismes") for "World Arthritis Day".
The scientific meeting highlighted the latest advances in research on rheumatic and musculoskeletal diseases. A discussion session with the patient associations was organised at the end of the day to communicate some of these advances in a language understandable by most people.

Programme

See the presentations delivered by the day’s speakers (Login: aviesan - Password: avies@n)
Organisation and Steering committee: Florence APPARAILLY, Thomas BARDIN, Francis BERENBAUM, Christian BOITARD, Maxime BREBAN, Lionel COMOLE, Caroline DREUILLET, René-Marc FLIPO, Laure GOSSEC, Nathalie GRIVEL, Jérôme GUICHEUX, Marie-Hélène LAFAGE-PROUST, Christian ROUX, Catherine REILLAT, Françoise RUSSO-MARIE, Jean SIBILIA

World Kidney Day: "Kidney Diseases and Ageing"

Thursday 13 Mars 2014 in the Académie nationale de médecine, 16 rue Bonaparte (Paris 6e)
This meeting of researchers, healthcare professionals and patient associations was held true to annual tradition, on World Kidney Day. The 2014 edition of the meetings, which took place on 13 March at the National Academy of Medicine, focused in kidney diseases and ageing.
Read the Event Gazette (in french)
View the presentations delivered by the day’s speakers (in french)

"Non-Coding RNA" Workshop

19 December 2013 in the Biopark Site Auditorium (Paris 13th Arrondissement)
This workshop was organised by the Circulation, Metabolism, Nutrition ITMO, in cooperation with the Genetics, Genomics and Bioinformatics ITMO. It focused primarily on non-coding RNA, with the aim of taking stock of the latest findings in the field and providing this recent data in genetics to the teams most focused on the physiopathology of diseases, the causes of which are often multi-factorial.
The workshop was the opportunity to bring together scientists and clinicians from a variety of fields, discuss on the topic of non-coding RNA, trigger reflection and foster future cooperation.
Scientific Committee: Dominique Daegelen, Joëlle Marie and Richard Moreau
Agenda

2nd Franco-German Symposium on Research in the Cardiovascular Field "Frontiers of Cardiovascular Research"

22 November 2013, Embassy of the Federal Republic of Germany in Paris
This symposium, jointly-organised by the Circulation, Metabolism, Nutrition ITMO and the Max-Delbrück Centre of Molecular Medicine in Berlin, brought together French and German experts from the field of cardiovascular research.
Open to all scientific community members, it was aimed at introducing the know-how of researchers from the two countries, foster discussion and spark new cooperation efforts. The day concluded with a Round Table on the financing opportunities for cooperative Franco-German projects.
For more information, visit the event’s site
Agenda and Posters

4th Annual Circulation, Metabolism, Nutrition ITMO Conference

3 October 2013, in the Petit Auditorium at Bibliothèque François-Mitterrand, Paris 13th Arrondissement
One of the scientific priorities set out by the CMN ITMO under its research strategy is the study of the multiple and complex interactions between organs, including dialogue between the central nervous system and peripheral tissue. For the 4th edition of its annual conference, the Circulation, Metabolism, Nutrition ITMO joined forces with the Neurosciences, Cognitive Sciences, Neurology and Psychiatrics ITMO to devise an agenda focused on central control of metabolic functions.
The agenda included two general lectures delivered by Matthias Tschöp (Helmholtz Centre in Munich, Germany) and Claudio Franceschi (University of Bologna, Italy).
Agenda

Workshop "Viewing Inflammation and Fibrosis"

26 June 2013 at the Plein Ciel Amphitheater, MGEN, in Paris (15th Arrondissement)
This workshop, organised by the Circulation, Metabolism, Nutrition ITMO was held on Wednesday 26 June 2013 at the Plein Ciel Amphitheater, MGEN, in Paris (15th Arrondissement).
It was the opportunity to explore the techniques currently used in animal imaging, at the cellular and tissular level, with a focus on inflammation and fibrosis. The workshop was aimed at sharing the experiments and expertise of French and European researchers and fostering interaction around these techniques, in order to best advise future users.
Agenda

"Young Researchers" Symposium held by the Circulation, Metabolism, Nutrition ITMO

16 May 2013, at the Adicare Auditorium, Institute of Cardiology, Pitié-Salpêtrière Hospital, Paris 13th Arrondissement
This symposium was designed to showcase the research projects developed in the CMN ITMO’s thematic areas by the young top-tier researchers who will be producing the research of the future, with the aim of sparking reflection and enabling new encounters. The agenda included two general lectures, given by Joël Nargeot (Institute of Functional Genomics, Montpellier) and Pierre Leopold (Valrose Institute of Biology, Nice).
Agenda

Meeting-Debate "Stop Kidney Damage" with patient associations

On 21 March 2013, National Academy of Medicine (16 rue Bonaparte, Paris 6th Arrondissement)
True to annual tradition, for World Kidney Day, a meeting-debate was organised by the Inserm Associations Task Force and Circulation, Metabolism, Nutrition ITMO, in partnership with 7 associations of patients affected by kidney diseases and the Kidney Foundation. The 2013 meeting focused on severe kidney failure and the influence of environmental and drug-related factors.
Read the Event’s Gazette (in french)

"The Contribution of ‘Omic’ Analysis to Biomedical Research in the Cardiovascular, Metabolic and Nutritional Fields" Workshop

6 Décembre 2012 in the Amphitheatre of INRA Headquarters (Paris 7th Arrondissement)
This workshop was organised by the Circulation, Metabolism, Nutrition and Genomics, Genetics and Bio-Informatics ITMOs. It was held on 6 December 2012 in the Amphitheatre of INRA Headquarters (Paris 7th Arrondissement)
Workshop Agenda

"Alcohol" Workshop

29 November 2012, Adicare Auditorium (Institute of Cardiology, Pitié Salpêtrière General Hospital, Paris 13th)
This workshop, organised by the Circulation, Metabolism, Nutrition and Public Health ITMOs, addressed the topic of alcohol from the societal, economic, biological and medical angles. Two international lectures were delivered, dealing with the economic impact of alcohol consumption and related diseases (Pr. Jürgen Rehm, Toronto, Canada) and addiction management (Pr. Karl Mann, University of Heidelberg, Germany). It was aimed at researchers, scientists, clinicians and players interested in the topic with the aim of stirring discussion and promoting future collaboration.
Scientific Committee: Jean-Charles Duclos-Vallée, Philippe Mathurin, Richard Moreau, Bertrand Nalpas, Philippe Sogni
Agenda

3rd Annual Circulation, Metabolism and Nutrition ITMO Conference

29 March 2012, Maison de la Chimie, Paris 7th Arrondissement
For its 3rd Edition, the CMN ITMO decided to honour promising young researchers dedicating their work to one of the topics covered by the Institute. Agenda highlights included two general lectures given by Jens C Brüning (University of Cologne, Germany) and Jean-Marc Reichhart (Institute of Molecular and Cellular Biology, University of Strasbourg).
Conference Agenda

 

 

 

 

The 2nd International Encounters of Biomedical Research, jointly organized by the International Research Laboratories (LIR), French Pharmaceutical Companies Association (LEEM) and Circulation, Metabolism and Nutrition thematic multi-organization institute, focused on cardiovascular and metabolic diseases
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Interview of Christian Boitard, Director of the thematic multi-organization institute Physiopathology, Metabolism, Nutrition

Medical challenges

Heart, blood vessels, lungs, endocrine glands, liver, kidneys, digestive tract, skin, bones, joints... not a single family today is spared the great many diseases affecting these organs. And in the space of two generations, obesity has become a plague in our affluent societies. 

Cardiovascular, respiratory, metabolic and nutritional diseases are very common and have devastating complications, and they therefore represent a major public health issue. Diabetes, hyperlipidaemia, obesity, kidney failure and atherosclerosis lead to cardiovascular diseases that are, alongside cancer, the main cause of death in industrialised societies.

Coronary disease, strokes and chronic heart failure account for 75% of cerebrovascular diseases and are alone responsible for 29% of deaths annually. Thrombotic diseases are very prevalent, arterial thrombosis (ischaemic diseases) and venous thrombosis (thrombo-embolic disease) are the world's leading cause of death. The prevalence of constitutional haemorrhagic diseases is limited, but their social and economic impact is significant, as in the case of haemophilia.

Respiratory diseases (asthma, chronic obstructive pulmonary disease, COPD; pulmonary fibroses) affect millions of people in France and their incidence is increasing. COPD alone already represents the third-largest cause of death in Europe (sixth in the world).

The prevalence of diabetes and glucose intolerance has now reached 7.1% and 5.6%, respectively, in France, affecting nearly 4 million people.

This prevalence follows a steadily rising trend, galloping in certain countries, parallel to that for obesity, that affects more than 15% of the adult population, but also the child and teenage populations. Hyperlipidaemia, obesity and diabetes are the cause of serious complications: vision disorders and blindness, strokes and heart attacks, neurological disorders, amputations, respiratory, liver and kidney problems.

These diseases, all cardiovascular risk factors, are all the more severe in their medical impact as they are often combined in the same patient. There has even been talk of a truemetabolic syndrome in patients presenting visceral (abdominal) obesity, dyslipidaemia (increased level of triglycerides and/or low level of HDL-cholesterol), high blood pressure, diabetes, blood clotting problems and kidney disorders (microalbuminuria). These are often associated with non-vascular complications such as hepatic steatoses, which generally lead to cirrhosis or arthrosis, for which obesity is itself a considerable aggravating factor. Very diverse populations are affected. In particular, several epidemiological studies suggest that people of non-European origins are most exposed to the risk.

Paradoxically, our societies are also facing the problem of malnutrition. It is estimated that nutritional deficiencies are still causing the deaths of 3 million children annually, essentially in developing countries. But malnutrition also affects 40% of patients suffering from chronic diseases, 30% to 50% of patients admitted to hospital (taking all illnesses combined), aggravating both the morbidity and mortality of patients. Normal ageing is also accompanied by frequent disruption to food intake leading to various deficiencies.

Diseases of the bones and joints are also a concern for the French, particularly due to ageing of the population. On their own they represent half of chronic diseases in people over 65 and are a major cause of invalidity (arthrosis is the second largest handicap factor in men, the fourth in women). Among the over 50s, one women in four and one man in eight will be affected by osteoporosis during their lives.

Skin diseases include a proportion of allergic complaints (atopic dermatitis, contact eczema, occupational dermatoses, photo-allergies, urticaria and skin accidents due to oral administration of a drug (toxicodermatitis)) and a proportion of chronic inflammatory disorders (psoriasis, atopic dermatitis, pelada, etc.). Among this latter group, psoriasis, affects between two and three million people in France and is associated with a significant change in the quality of life, often leading to a severe social handicap. The impact of this dermatosis on the quality of life is as significant as that caused by asthma, diabetes or chronic cardiac ischaemic diseases. The social cost of psoriasis is therefore considerable. Ageing of the population is accompanied is increasingly frequently accompanied by chronic vascular complaints of the lower limbs. Their treatment is complex and should be multi-disciplinary, ideally as part of a care network led by dermatologists specialised in the field of cicatrisation.


Director : Christian Boitard

Co-director : Jean Dallongeville

Policy Officers: Nathalie Grivel, Raymond Bazin

Contact: itmoPMN@aviesan.fr

Experts Committee: Jean-François Arnal (PU-PH), Francis Berenbaum (PU-PH), Chantal Boulanger (DR, Inserm), Nadine Cerf-Bensussan (DR, Inserm), Jean Dallongeville (DR, Inra), Barbara Demeneix (PR, MNHN), Chloé Féral (DR2, Inserm), Marc Humbert (PU-PH), Christophe Junot (Chercheur, CEA), Armelle Leturque (DR, CNRS), Michael Lukasiewicz (Directeur médical, ARIIS), Roger Marthan (PU-PH), Renato Monteiro (PU-PH), Richard Moreau (DR, Inserm), Luc Pénicaud (DR, CNRS), Mickaël Tanter (DR, Inserm)
 

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