ITMO BMSV: “Frontiers of Chemical Biology: Investigating life with chemistry”




Structure cristallographique du récepteur nucléaire RXRa (hélices colorées et surface moléculaire grise) contenant une molécule de tributylétain (TBT, sphères magentas et grise), un perturbateur endocrinien environnemental. Centre de biochimie structurale ; © W. Bourguet

6 June 2014, Marie Curie lecture theatre, CNRS (3, rue Michel Ange, 75016 Paris)

Organised by: The multi-organizational thematic institute for 'Molecular and Structural Bases of Living Things' (part of the Aviesan alliance). Title: "Frontiers of Chemical Biology: Investigating life with chemistry".

This day conference will offer a series of talks on the topic of chemical biology by both leading international figures in the field and younger researchers. The conference will provide an opportunity to define and present this scientific discipline, which covers the fields of chemistry and biology and involves the development of chemistry-based tools and methods for studying and experimenting with biological systems. There will be special emphasis on its applications in cell biology.
A poster and flash presentation session is planned (see submission procedure).

Registration website:



Conference program:

Introduction : Jean-Claude Michalski (Dir. ITMO BMSV)

SESSION 1 : Introduction and chemistry in living cell - Chair : Anne Imberty (Grenoble)

SESSION 2 : Chemical biology of proteins and peptides - Chair : Agnès Delmas (Orléans)

  • Chemical modification of proteins in vitro and on live cells using protein trans-splicing – Henning Mootz (Münster)
  • Chemically-modified proteins as tools designed to explore biological systems – Vincent Aucagne (Orléans)
  • Flash presentations (details below)

SESSION 3 : Chemistry for imaging and modeling - Chair : Pascal George (Châtenay-Malabry)

SESSION 4 : Chemical biology of nucleic acids - Chair : Carine Giovannangeli (Paris)

  • Small Molecules, Big Players – Raphael Rodriguez (Gif-sur-Yvette)
  • Imaging RNA and RNA biology using RNA mimics of green fluorescent protein - Samie Jaffrey (New York)

Conclusion : Agnès Delmas, Anne Imberty and Pascal George, representing the Société de Chimie Thérapeutique (SCT)



Flash presentations :

  • Broad profiling prediction of protein kinase inhibitors via kinochemometrics approach - Nicolas Bosc (Orléans)
  • Light-activated proteolysis for remote control of proteins - Quentin Delacour (Paris)
  • Lanthanide(III)-based polyamidoamine dendrimers as visible and near-infrared imaging probes - Svetlana Eliseeva (Orléans)
  • Synthesis of peptidyl-RNA conjugates for structural and mechanistic study of FemXwv aminoacyl transferase - Mélanie Etheve-Quelquejeu (Paris)
  • Cu ligands with high selectivity over Zn to combat Alzheimer’s disease - Christelle Hureau (Toulouse)
  • Towards semi-synthetic n-glucosylated mog to identify aberrantly modified native protein autoantigens in multiple sclerosis - Maud Larregola (Cergy-Pontoise)
  • Heparan sulfate-protein chemical biology for therapeutic innovation - Christine Le Narvor (Orsay)
  • Targeting epigenetic factors and DNA methylation: towards development of novel anticancer therapies - Marie Lopez (Toulouse)
  • Out-of-phase imaging after optical modulation (opiom) for selective imaging of photoconvertible proteins – Jérôme Quérard (Paris)
  • Polymer photoswitches to manipulate lipid membranes and cells with light - Christophe Tribet (Paris)
  • Degradable hybrid materials based on cationic acylhydrazone dynamic covalent polymers promote DNA complexation through multivalent interactions - Sebastien Ulrich (Montpellier)
  • Brief presentation of “GDR ChemBioScreen: A French network for chemical biology” - Laurence Lafanechère (Grenoble)
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